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Journal Articles

Building a Partnership Between a University and Local High School to Foster and Grow Interest in Biomedical Sciences and Engineering

Ryan M. Castile, Jamie Jobe, Leanne E. Iannucci, Rebecca F. Reals, Shawn N. Pavey, Jon Fitzgerald, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. May 2024, 146(5): 054503.
Paper No: BIO-23-1273
https://doi.org/10.1115/1.4064664
Published Online: March 7, 2024
View Articletitled, Building a Partnership Between a University and Local High School to Foster and Grow Interest in Biomedical Sciences and Engineering
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Topics: Biomedicine, Students, Graduate students
Journal Articles

Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture

Alex J. Reiter, Griffin J. Kivitz, Ryan M. Castile, Paul C. Cannon, Emily H. Lakes, Brittany Y. Jacobs, Kyle D. Allen, Aaron M. Chamberlain, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2019, 141(7): 071001.
Paper No: BIO-18-1551
https://doi.org/10.1115/1.4043433
Published Online: May 23, 2019
View Articletitled, Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture
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Topics: Mechanical testing, Spatiotemporal phenomena, Testing, Wounds, Weight (Mass)
Journal Articles

Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration

Jeremy D. Eekhoff, Fei Fang, Lindsey G. Kahan, Gabriela Espinosa, Austin J. Cocciolone, Jessica E. Wagenseil, Robert P. Mecham, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2017, 139(11): 111003.
Paper No: BIO-17-1362
https://doi.org/10.1115/1.4037932
Published Online: September 27, 2017
View Articletitled, Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration
Open the PDF for Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration in another window
Topics: Air traffic control, Fibers, Tendons, Stress, Mechanical properties
Journal Articles

Validation of Single C-Arm Fluoroscopic Technique for Measuring In Vivo Abdominal Wall Deformation

Lindsey G. Kahan, Charlotte Guertler, Jeffrey A. Blatnik, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2017, 139(8): 084502.
Paper No: BIO-17-1021
https://doi.org/10.1115/1.4037073
Published Online: June 28, 2017
View Articletitled, Validation of Single C-Arm Fluoroscopic Technique for Measuring In Vivo Abdominal Wall Deformation
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Topics: Calibration, Errors, Imaging, Deformation, Matlab, Algorithms, Maintenance
Journal Articles

Multiscale Mechanical Evaluation of Human Supraspinatus Tendon Under Shear Loading After Glycosaminoglycan Reduction

Fei Fang, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2017, 139(7): 071013.
Paper No: BIO-16-1488
https://doi.org/10.1115/1.4036602
Published Online: June 6, 2017
View Articletitled, Multiscale Mechanical Evaluation of Human Supraspinatus Tendon Under Shear Loading After Glycosaminoglycan Reduction
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Topics: Biological tissues, Biomechanics, Enzymes, Equilibrium (Physics), Shear (Mechanics), Stress, Tendons, Mechanical properties, Microscale devices, Deformation
Journal Articles

Pronation–Supination Motion Is Altered in a Rat Model of Post-Traumatic Elbow Contracture

Chelsey L. Dunham, Ryan M. Castile, Aaron M. Chamberlain, Leesa M. Galatz, Spencer P. Lake
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2017, 139(7): 071011.
Paper No: BIO-16-1487
https://doi.org/10.1115/1.4036472
Published Online: June 6, 2017
View Articletitled, Pronation–Supination Motion Is Altered in a Rat Model of Post-Traumatic Elbow Contracture
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Topics: Mechanical testing, Surgery, Wounds
Proceedings Papers

Swelling of Collagen-Hyaluronic Acid Tissue-Equivalents: An Experimental Model to Evaluate Residual Stress in Soft Tissues

Victor K. Lai, Spencer P. Lake, Bumjun Kim, Emily M. Weiss, Robert T. Tranquillo, Victor H. Barocas
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT54A002, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14609
https://doi.org/10.1115/SBC2013-14609
View Paper titled, Swelling of Collagen-Hyaluronic Acid Tissue-Equivalents: An Experimental Model to Evaluate Residual Stress in Soft Tissues
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Topics: Biological tissues, Soft tissues, Stress, Annulus, Blood vessels, Fibers, Manufacturing, Water
Proceedings Papers

A Hyperelastic Model With Distributed Fibers to Describe Human Supraspinatus Tendon Tensile Mechanics

Jennifer A. Kadlowec, Spencer P. Lake, Kristin S. Miller, Louis J. Soslowsky, Dawn M. Elliott
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 679-680, June 17–21, 2009
Publisher: American Society of Mechanical Engineers
Paper No: SBC2009-206509
https://doi.org/10.1115/SBC2009-206509
View Paper titled, A Hyperelastic Model With Distributed Fibers to Describe Human Supraspinatus Tendon Tensile Mechanics
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Topics: Fibers, Tendons, Mechanical behavior, Anisotropy, Biological tissues, Constitutive equations, Design, Materials properties
Proceedings Papers

Collagen Network Architecture Varies Between Pure Collagen and Collagen-Fibrin Co-Gels

Victor K. Lai, Allan M. Kerandi, Spencer P. Lake, Robert T. Tranquillo, Victor H. Barocas
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1219-1220, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80738
https://doi.org/10.1115/SBC2012-80738
View Paper titled, Collagen Network Architecture Varies Between Pure Collagen and Collagen-Fibrin Co-Gels
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Topics: Biological tissues, Design, Dimensions, Engineers, Mechanical behavior, Modeling, Polymers, Proteins, Tissue engineering
Proceedings Papers

Elucidation of Microstructural Interactions Between Collagen and Non-Fibrillar Matrix in Soft Tissue Using a Coupled Fiber-Matrix Model

Lijuan Zhang, Spencer P. Lake, Victor K. Lai, Victor H. Barocas, Mark S. Shephard
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 167-168, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80401
https://doi.org/10.1115/SBC2012-80401
View Paper titled, Elucidation of Microstructural Interactions Between Collagen and Non-Fibrillar Matrix in Soft Tissue Using a Coupled Fiber-Matrix Model
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Topics: Fibers, Soft tissues, Biological tissues, Stress, Agar, Composite materials, Damage, Diseases, Mechanical properties, Microscale devices
Proceedings Papers

Inhomogeneous and Nonlinear Transverse Tensile Properties and Fiber Alignment of Human Supraspinatus Tendon

Spencer P. Lake, Kristin S. Miller, Jennifer A. Kadlowec, Dawn M. Elliott, Louis J. Soslowsky
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 123-124, June 17–21, 2009
Publisher: American Society of Mechanical Engineers
Paper No: SBC2009-206483
https://doi.org/10.1115/SBC2009-206483
View Paper titled, Inhomogeneous and Nonlinear Transverse Tensile Properties and Fiber Alignment of Human Supraspinatus Tendon
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Topics: Fibers, Tendons, Tensile strength, Mechanical properties, Biological tissues, Stress, Anisotropy, Testing
Proceedings Papers

Collagen-Agarose Co-Gels as a Model for Collagen-Matrix Interaction in Soft Tissue

Spencer P. Lake, Sadie Doggett, Victor H. Barocas
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1351-1352, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53640
https://doi.org/10.1115/SBC2011-53640
View Paper titled, Collagen-Agarose Co-Gels as a Model for Collagen-Matrix Interaction in Soft Tissue
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Topics: Agar, Soft tissues, Fibers, Biological tissues, Mechanical behavior, Mechanical properties, Shear (Mechanics), Storage, Tension
Proceedings Papers

Collagen Network Topology is Influenced by Collagen Concentration, But Not by Co-Gelation With Fibrin

Victor K. Lai, Edward A. Sander, Spencer P. Lake, Robert T. Tranquillo, Victor H. Barocas
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1187-1188, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53239
https://doi.org/10.1115/SBC2011-53239
View Paper titled, Collagen Network Topology is Influenced by Collagen Concentration, But Not by Co-Gelation With Fibrin
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Topics: Biological tissues, Cardiovascular system, Mechanical properties, Modeling, Proteins, Strength (Materials), Thrombosis, Tissue engineering, Topology
Proceedings Papers

Initial Collagen Fiber Alignment Determines the Mechanical and Structural Response of Cell-Compacted Tissue-Equivalents Under Indentation

Spencer P. Lake, Victor H. Barocas
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 889-890, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53448
https://doi.org/10.1115/SBC2011-53448
View Paper titled, Initial Collagen Fiber Alignment Determines the Mechanical and Structural Response of Cell-Compacted Tissue-Equivalents Under Indentation
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Topics: Biological tissues, Fibers, Stress, Soft tissues, Tendons, Bone, Density, Geometry, Imaging, Kinematics
Proceedings Papers

Anisotropic Inverse Mechanics Identifies Regional Changes in Mechanical Anisotropy During Remodelling of Fibroblast-Populated Collagen Cruciforms

Ramesh Raghupathy, Spencer P. Lake, Edward A. Sander, Colleen Witzenburg, Victor H. Barocas
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1295-1296, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53177
https://doi.org/10.1115/SBC2011-53177
View Paper titled, Anisotropic Inverse Mechanics Identifies Regional Changes in Mechanical Anisotropy During Remodelling of Fibroblast-Populated Collagen Cruciforms
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Topics: Anisotropy, Fibroblasts, Biological tissues, Isotropy, Polarimetry, Soft tissues
Proceedings Papers

Comparison of Experimental and Affine-Predicted Fiber Kinematics in Human Supraspinatus Tendon

Spencer P. Lake, Daniel H. Cortes, Jennifer A. Kadlowec, Dawn M. Elliott, Louis J. Soslowsky
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 319-320, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19234
https://doi.org/10.1115/SBC2010-19234
View Paper titled, Comparison of Experimental and Affine-Predicted Fiber Kinematics in Human Supraspinatus Tendon
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Topics: Fibers, Kinematics, Tendons, Biological tissues, Deformation, Modeling, Soft tissues, Anisotropy, Testing
Proceedings Papers

Generalized Anisotropic Inverse Mechanics: Mechanical Anisotropy Correlates With Structural Anisotropy in Collagen Based Tissue Equivalents

Ramesh Raghupathy, Spencer P. Lake, Edward A. Sander, Victor H. Barocas
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 897-898, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19215
https://doi.org/10.1115/SBC2010-19215
View Paper titled, Generalized Anisotropic Inverse Mechanics: Mechanical Anisotropy Correlates With Structural Anisotropy in Collagen Based Tissue Equivalents
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Topics: Anisotropy, Biological tissues, Bearings, Blood vessels, Damage, Diseases, Fibers, Soft tissues, Stress
Proceedings Papers

Mechanical Contribution of Fiber Angular Distribution in Connective Tissue: Comparison of Two Modeling Approaches

Daniel H. Cortes, Spencer P. Lake, Jennifer A. Kadlowec, Louis J. Soslowsky, Dawn M. Elliott
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 453-454, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19126
https://doi.org/10.1115/SBC2010-19126
View Paper titled, Mechanical Contribution of Fiber Angular Distribution in Connective Tissue: Comparison of Two Modeling Approaches
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Topics: Biological tissues, Fibers, Modeling, Tensors, Stress, Tension, Algorithms, Cartilage, Compression, Finite element analysis
Journal Articles

A Coupled Fiber-Matrix Model Demonstrates Highly Inhomogeneous Microstructural Interactions in Soft Tissues Under Tensile Load

Lijuan Zhang, Spencer P. Lake, Victor K. Lai, Catalin R. Picu, Victor H. Barocas, Mark S. Shephard
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2013, 135(1): 011008.
Paper No: BIO-12-1323
https://doi.org/10.1115/1.4023136
Published Online: December 27, 2012
View Articletitled, A Coupled Fiber-Matrix Model Demonstrates Highly Inhomogeneous Microstructural Interactions in Soft Tissues Under Tensile Load
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Topics: Fibers, Stress, Soft tissues
Journal Articles

Mechanical Behavior of Collagen-Fibrin Co-Gels Reflects Transition From Series to Parallel Interactions With Increasing Collagen Content

Victor K. Lai, Spencer P. Lake, Christina R. Frey, Robert T. Tranquillo, Victor H. Barocas
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. January 2012, 134(1): 011004.
https://doi.org/10.1115/1.4005544
Published Online: February 9, 2012
View Articletitled, Mechanical Behavior of Collagen-Fibrin Co-Gels Reflects Transition From Series to Parallel Interactions With Increasing Collagen Content
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Topics: Failure, Mechanical behavior, Mechanical properties, Mechanical testing, Modeling, Stress, Tensile strength, Composite materials, Tissue engineering, Fibers