Bioceramics with porous microstructure has attracted intense attention in tissue engineering due to tissue growth facilitation in the human body. In the present work, a novel manufacturing process for producing hydroxyapatite (HA) aerogels with a high density shell inspired by human bone microstructure is proposed for bone tissue engineering applications. This method combines laser processing and traditional freeze casting, in which HA aerogel is prepared by freeze casting and aqueous suspension prior to laser processing of the aerogel surface with a focused CO2 laser beam that forms a dense layer on top of the porous microstructure. Using the proposed method, HA aerogel with dense shell was successfully prepared with a microstructure similar to human bone. The effect of laser process parameters on the surface, cross-sectional morphology and microstructure was investigated in order to obtain optimum parameters and has a better understanding of the process. Low laser energy resulted in a fragile thin surface with defects and cracks due to the thermal stress induced by the laser processing. However, increasing the laser power generated a thicker dense layer on the surface, free of defects. The range of 40–45 W laser power, 5 mm/s scanning speed, spot size of 1 mm, and 50% overlap in laser scanning the surface yielded the best surface morphology and microstructure in our experiments.
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March 2018
This article was originally published in
Journal of Micro and Nano-Manufacturing
Research-Article
Laser Surface Engineering of Hierarchy Hydroxyapatite Aerogel for Bone Tissue Engineering
Pedram Parandoush,
Pedram Parandoush
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: pedramp@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: pedramp@ksu.edu
Search for other works by this author on:
Hanxiong Fan,
Hanxiong Fan
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Hanxiong@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Hanxiong@ksu.edu
Search for other works by this author on:
Xiaolei Song,
Xiaolei Song
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: xiaoleisong@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: xiaoleisong@ksu.edu
Search for other works by this author on:
Dong Lin
Dong Lin
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Dongl@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Dongl@ksu.edu
Search for other works by this author on:
Pedram Parandoush
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: pedramp@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: pedramp@ksu.edu
Hanxiong Fan
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Hanxiong@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Hanxiong@ksu.edu
Xiaolei Song
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: xiaoleisong@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: xiaoleisong@ksu.edu
Dong Lin
Department of Industrial and
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Dongl@ksu.edu
System Engineering,
Kansas State University,
2061 Rathbone Hall, 66506,
1701B Platt Street,
Manhattan, KS 66502
e-mail: Dongl@ksu.edu
Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received September 12, 2017; final manuscript received November 28, 2017; published online December 26, 2017. Editor: Jian Cao.
J. Micro Nano-Manuf. Mar 2018, 6(1): 011007 (6 pages)
Published Online: December 26, 2017
Article history
Received:
September 12, 2017
Revised:
November 28, 2017
Citation
Parandoush, P., Fan, H., Song, X., and Lin, D. (December 26, 2017). "Laser Surface Engineering of Hierarchy Hydroxyapatite Aerogel for Bone Tissue Engineering." ASME. J. Micro Nano-Manuf. March 2018; 6(1): 011007. https://doi.org/10.1115/1.4038669
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