Abstract

For diagnosis of secondary lymphedema, amplitude mode (A-mode) examination using a single ultrasound probe has been suggested as one of the possible diagnostic modalities due to its relatively low cost, ease of usage, and mobility. However, A-mode ultrasound waves with respect to time have lots of noise and are complicated to analyze and achieve well-correlated information related to change in volume of each layer of skin and subcutaneous tissues. Thus, the development of an adequate ultrasound calibration phantom is needed. For this, a fundamental study on proper phantom materials which show acoustic characteristics of skin and subcutaneous tissues is needed. In this research, the fabrication method for ultrasonic phantom using gelatin material is presented in a wide range of acoustic impedance and their acoustic characteristics and usability were discussed.

References

1.
Kim
,
C.
,
Kang
,
S. S.
, and
Kim
,
J.
,
2016
, “
Evaluation of Quantitative Image Quality Using Frequency and Parameters in the Ultrasound Image
,”
J. Korean Soc. Radiol.
,
10
(
4
), pp.
247
252
.10.7742/jksr.2016.10.4.247
2.
Madsen
,
E. L.
,
Zagzebski
,
J. A.
,
Banjavie
,
R. A.
, and
Jutila
,
R. E.
,
1978
, “
Tissue Mimicking Materials for Ultrasound Phantoms
,”
Medical Phys.
,
5
(
5
), pp.
391
394
.10.1118/1.594483
3.
Burlew
,
M. M.
,
Madsen
,
E. L.
,
Zagzebski
,
J. A.
,
Banjavic
,
R. A.
, and
Sum
,
S. W.
,
1980
, “
A New Ultrasound Tissue-Equivalent Material
,”
Radiat. Phys.
,
134
(
2
), pp.
517
520
.10.1148/radiology.134.2.7352242
4.
Lee
,
G. J.
,
Park
,
D. H.
,
Shin
,
T. N.
, and
Seo
,
J. B.
,
2008
, “
Analysis of Properties and Phantom Design Based on Plastic Harderner and Softener for Ultrasonic Imaging
,”
J. Biomed. Eng. Res.
,
29
(
4
), pp.
302
306
.https://www.semanticscholar.org/paper/Analysis-of-Properties-and-Phantom-Design-Basedon-Lee-Park/b931f65a9d22432a5e6bef2a0c90e58dfdf5415b
5.
Culjat
,
M. O.
,
Goldenberg
,
D.
,
Tewari
,
P.
, and
Singh
,
R. S.
,
2010
, “
A Review of Tissue Substitutes for Ultrasound Imaging
,”
Ultrasound Med. Biol.
,
36
(
6
), pp.
861
73
.10.1016/j.ultrasmedbio.2010.02.012
6.
Hall
,
T. J.
,
Bilgen
,
M.
,
Insana
,
M. F.
, and
Krouskop
,
T. A.
,
1997
, “
Phantom Materials for Elastography
,”
IEEE Trans. Ultrason. Ferroelectr. Freq. Control
,
44
(
6
), pp.
1355
1365
.10.1109/58.656639
7.
Kondo
,
T.
,
Kitatuji
,
M.
, and
Kanda
,
H.
,
2005
, “
New Tissue Mimicking Materials for Ultrasound Phantoms
,”
Proc. IEEE Ultrasonic Symposium
, Rotterdam, The Netherlands, Sept. 18–21, pp.
1664
1667
.10.1109/ULT SYM.2005.1603183
8.
Cafarelli
,
A.
,
Verbeni
,
A.
,
Poliziani
,
A.
,
Dario
,
A.
,
Menciassi
,
A.
, and
Ricotti
,
L.
,
2017
, “
Tuning Acoustic and Mechanical Properties of Materials for Ultrasound Phantoms and Smart Substrates for Cell Cultures
,”
Acta Biomater.
,
49
, pp.
368
378
.10.1016/j.actbio.2016.11.049
9.
Cheng
,
J.
,
Howard
,
I. C.
, and
Rennison
,
M.
,
2010
, “
Study of an Infant Brain Subjected to Periodic Motion Via a Custom Experimental Apparatus Design and Finite Element Modelling
,”
J. Biomech.
,
43
(
15
), pp.
2887
2896
.10.1016/j.jbiomech.2010.07.023
10.
Balakrishnan
,
B.
,
Joshi
,
N.
,
Jayakrishnan
,
A.
, and
Banerjee
,
R.
,
2014
, “
Self-Crosslinked Oxidized Alginate/Gelatin Hydrogel as Injectable, Adhesive Biomimetic Scaffolds for Cartilage Regeneration
,”
Acta Biomaterialia
,
10
(
8
), pp.
3650
3663
.10.1016/j.actbio.2014.04.031
11.
Whu
,
S. W.
,
Hung
,
K. C.
,
Hsieh
,
K. H.
,
Chen
,
C. H.
,
Tsai
,
C. L.
, and
Hsu
,
S. H.
,
2013
, “
In Vitro and In Vivo Evaluation of Chitosan-Gelatin Scaffolds for Cartilage Tissue Engineering
,”
Mater. Sci. Eng.: C
,
33
(
5
), pp.
2855
2863
.10.1016/j.msec.2013.03.003
12.
Schuringa
,
O.
,
2017
, “
Density and Viscosity Calculation Using Ultrasonic Wave Propagation
,”
Thesis of B.S degree
,
Delft University of Technology
, Delft, The Netherlands, pp.
5
6
.https://d1rkab7tlqy5f1.cloudfront.net/TNW/Afdelingen/Radiation%20Science%20and%20Technology/Research%20Groups/RPNM/Publications/BSc_Olivier_Schuringa.pdf
13.
Hoche
,
S.
,
Hussein
,
M. A.
, and
Becker
,
T.
,
2015
, “
Density, Ultrasound Velocity, Acoustic Impedance, Reflection and Absorption Coefficient Determination of Liquids Via Multiple Reflection Method
,”
Ultrasonics
,
57
, pp.
65
71
.10.1016/j.ultras.2014.10.017
14.
Hu
,
M.
,
Azeloglu
,
E. U.
,
Ron
,
A.
,
Tran-Ba
,
K.-H.
,
Calizo
,
R. C.
,
Tavassoly
,
I.
,
Bhattacharya
,
S.
,
Jayaraman
,
G.
,
Chen
,
Y.
,
Rabinovich
,
V.
,
Iyengar
,
R.
,
Hone
,
J. C.
,
He
,
J. C.
, and
Kaufman
,
L. J.
,
2017
, “
A Biomimetic Gelatin-Based Platform Elicits a Pro-Differntiation Effect on Podocytes Through Mechanotransduction
,”
Sci. Rep.
,
7
(
1
), pp.
1
13
.10.1038/srep43934
15.
Kim
,
K. Y.
,
Min
,
D. S.
,
Park
,
S. H.
,
Cho
,
Y. J.
,
Chung
,
Y. H.
,
Kim
,
J. M.
,
Chung
,
H. S.
, and
Hwang
,
S. J.
,
1989
, “
Development of Sponge-Like Artificial Skin From Gelatin
,”
Polymer (Korea)
,
13
(
5
), pp.
454
460
.https://www.cheric.org/PDF/PK/PK13/PK13-5-0454.pdf
16.
Exptl
,
J.
,
1963
, “
On the Theory of the Absorption of Ultrasound in Superconductors
,”
Sov. Phys. JETP
,
16
(
4
), pp.
945
950
.http://83.149.229.155/cgi-bin/dn/e_016_04_0945.pdf
17.
Budday
,
S.
,
Ovaert
,
T. C.
,
Holzapfel
,
G. A.
,
Steinmann
,
P.
, and
Kuhl
,
E.
,
2020
, “
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
,”
Arch. Comput. Methods Eng.
,
27
(
4
), pp.
1187
1230
.10.1007/s11831-019-09352-w
18.
Ahmed
,
R. L.
,
Prizment
,
A.
,
Lazovich
,
D.
,
Schmitz
,
K. H.
, and
Folsom
,
A. R.
,
2008
, “
Lymphedema and Quality of Life in Breast Cancer Survivors: The Iowa Women's Health Study
,”
J. Clinical Oncol.
,
26
(
35
), pp.
5689
5696
.10.1200/JCO.2008.16.4731
19.
McWayne
,
J.
, and
Heiney
,
S. P.
,
2005
, “
Psychologic and Social Sequelae of Secondary Lymphedema a Review
,”
Cancer
,
104
(
3
), pp.
457
466
.10.1002/cncr.21195
20.
Stanton
,
A. W.
,
Northfield
,
J. W.
,
Holroyd
,
B.
,
Mortimer
,
P. S.
, and
Levick
,
J. R.
,
1997
, “
Validation of an Optoelectronic Limb Volumeter (Perometer)
,”
Lymphology
,
30
(
2
), pp.
77
97
.https://pubmed.ncbi.nlm.nih.gov/9215977/
21.
Bednarczyk
,
J. H.
,
Hershler
,
C.
, and
Cooper
,
D. G.
,
1992
, “
Development and Clinical Evaluation of a Computerized Limb Volume Measurement System (CLEMS
),”
Arch. Phys. Med. Rehabil.
,
73
(
1
), pp.
60
63
.10.5555/uri:pii:000399939290228O
22.
Cornish
,
B. H.
,
Bunce
,
I. H.
,
Ward
,
L. C.
,
Jones
,
L. C.
, and
Thomas
,
B. J.
,
1996
, “
Bioelectrical Impedance for Monitoring the Efficacy of Lymphoedema Treatment Programmers
,”
Breast Cancer Res. Treat.
,
38
(
2
), pp.
169
176
.10.1007/BF01806671
23.
Cornish
,
B. H.
,
Chapman
,
M.
,
Hirst
,
C.
,
Mirolo
,
B.
,
Bunce
,
I. H.
,
Ward
,
L. C.
, and
Thomas
,
B. J.
,
2001
, “
Early Diagnosis of Lymphedema Using Multiple Frequency Bioimpedance
,”
Lymphology
,
34
(
1
), pp.
2
11
.https://pubmed.ncbi.nlm.nih.gov/11307661/
24.
Nuutinen
,
J.
,
Ikaheimo
,
R.
, and
Lahtinen
,
T.
,
2004
, “
Validation of a New Dielectric Device to Assess Changes of Tissue Water in Skin and Subcutaneous Fat
,”
Physiological Meas.
,
25
(
2
), pp.
447
54
.10.1088/0967-3334/25/2/004
25.
Chung
,
S. H.
, and
Kim
,
K. G.
,
2018
, “
Design of Lymphedema Ultrasound Phantom With 3D-Printed Patient-Specific Subcutaneous Anatomy: A-Mode Analysis Approach for Early Diagnosis
,”
Phys. Medica
,
55
, pp.
73
81
.10.1016/j.ejmp.2018.10.019
You do not currently have access to this content.