Restenosis after stent implantation is a major limitation of revascularization technique. Retrieving the stent safely and smoothly after the vascular remodeling is completed shows important clinical value. In this paper, a novel retrievable peripheral vascular stent and its modified retrieval platform were developed and a finite element analysis (FEA) model was established to study the retrieval process of the stent. Meanwhile, the safety and feasibility of the retrievable stent were assessed through in vivo experiments. The maximum strain of the stent is 6.87% during the whole retrieval process, which is less than the ultimate elastic strain of nitinol alloy. The simulation results indicate that the stent is not damaged during the whole retrieval process. Finally, the stents were implanted into Bama miniature pigs to assess the retrieval process, and the results suggest that the stents can be retrieved successfully within 30 min after implantation, and minor local mechanical injury can be found in the intimal layer of the blood vessel due to the deployment and retrieval of the stent. Studies presented in this work illustrate the feasibility of a novel retrievable peripheral vascular stent, providing an additional avenue to reduce the risk of restenosis.