The multiphotodiode array (MPA) is a novel transmission photoplethysmography (PPG) sensor to measure pulse wave velocity (PWV) in the finger. To validate the MPA, a setup was built to generate a red laser dot traveling over the MPA with known and constant scanning velocities. These scanning velocities were chosen to include speeds at least twice as high as those found in the normal range of PWV in healthy populations and were set at 12.9, 25.8, 36, or 46.7 m/s. The aim of this study was to verify the functionality of the MPA: performing local noninvasive PWV measurements. To illustrate the applicability of the MPA in clinical practice, an in vivo pilot study was conducted using the flow-mediated dilation (FMD) technique. The in vitro accuracy of the MPA was ±0.2%, 0.3%, 0.5%, and 0.6% at the applied scanning velocities. The MPA can measure PWVs with a maximum deviation of 3.0%. The in vivo pilot study showed a PWV before the FMD of 1.1±0.2 m/s. These results suggest that this novel MPA can reliably and accurately measure PWV within clinically relevant ranges and even well beyond.
Issue Section:
Research Papers
Topics:
Blood,
Design,
Lasers,
Photodiodes,
Sensors,
Testing,
Waves,
Mirrors,
Flow (Dynamics),
Pressure,
Signals,
Trajectories (Physics)
References
1.
Quinn
, U.
, Tomlinson
, L. A.
, and Cockcroft
, J. R.
, 2012
, “Arterial Stiffness
,” JRSM Cardiovasc. Dis.
, 1
(6
), pp. 1–8.2.
Blacher
, J.
, Guerin
, A. P.
, Pannier
, B.
, Marchais
, S. J.
, Safar
, M. E.
, and London
, G. M.
, 1999
, “Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
,” Circulation
, 99
(18
), pp. 2434
–2439
.3.
Laurent
, S.
, Boutouyrie
, P.
, Asmar
, R.
, Gautier
, I.
, Laloux
, B.
, Guize
, L.
, Ducimetiere
, P.
, and Benetos
, A.
, 2001
, “Aortic Stiffness is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients
,” Hypertension
, 37
(5
), pp. 1236
–1241
.4.
Cruickshank
, K.
, Riste
, L.
, Anderson
, S. G.
, Wright
, J. S.
, Dunn
, G.
, and Gosling
, R. G.
, 2002
, “Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance: An Integrated Index of Vascular Function?
,” Circulation
, 106
(16
), pp. 2085
–2090
.5.
Laurent
, S.
, Cockcroft
, J.
, Van Bortel
, L.
, Boutouyrie
, P.
, Giannattasio
, C.
, Hayoz
, D.
, Pannier
, B.
, Vlachopoulos
, C.
, Wilkinson
, I.
, and Struijker-Boudier
, H.
, and European Network for Non-Invasive Investigation of Large Arteries
, 2006
, “Expert Consensus Document on Arterial Stiffness: Methodological Issues and Clinical Applications
,” Eur. Heart J.
, 27
(21
), pp. 2588
–2605
.6.
Boutouyrie
, P.
, and Vermeersch
, S. J.
, 2010
, “Determinants of Pulse Wave Velocity in Healthy People and in the Presence of Cardiovascular Risk Factors: Establishing Normal and Reference Values
,” Eur. Heart J.
, 31
(19
), pp. 2338
–2350
.7.
Bramwell
, J. C.
, and Hill
, A. V.
, 1922
, “The Velocity of the Pulse Wave in Man
,” Proc. R. Soc. London, Ser. B
, 93
(652
), pp. 298
–306
.8.
Wilkinson
, I. B.
, Fuchs
, S. A.
, Jansen
, I. M.
, Spratt
, J. C.
, Murray
, G. D.
, Cockcroft
, J. R.
, and Webb
, D. J.
, 1998
, “Reproducibility of Pulse Wave Velocity and Augmentation Index Measured by Pulse Wave Analysis
,” J. Hypertens.
, 16
(12
), pp. 2079
–2084
.9.
Mancia
, G.
, Fagard
, R.
, Narkiewicz
, K.
, Redon
, J.
, Zanchetti
, A.
, Böhm
, M.
, Christiaens
, T.
, Cifkova
, R.
, De Backer
, G.
, Dominiczak
, A.
, Galderisi
, M.
, Grobbee
, D. E.
, Jaarsma
, T.
, Kirchhof
, P.
, Kjeldsen
, S. E.
, Laurent
, S.
, Manolis
, A. J.
, Nilsson
, P. M.
, Ruilope
, L. M.
, Schmieder
, R. E.
, Sirnes
, P. A.
, Sleight
, P.
, Viigimaa
, M.
, Waeber
, B.
, Zannad
, F.
, Burnier
, M.
, Ambrosioni
, E.
, Caufield
, M.
, Coca
, A.
, Olsen
, M. H.
, Tsioufis
, C.
, Van De Borne
, P.
, Zamorano
, J. L.
, Achenbach
, S.
, Baumgartner
, H.
, Bax
, J. J.
, Bueno
, H.
, Dean
, V.
, Deaton
, C.
, Erol
, C.
, Ferrari
, R.
, Hasdai
, D.
, Hoes
, A. W.
, Knuuti
, J.
, Kolh
, P.
, Lancellotti
, P.
, Linhart
, A.
, Nihoyannopoulos
, P.
, Piepoli
, M. F.
, Ponikowski
, P.
, Tamargo
, J. L.
, Tendera
, M.
, Torbicki
, A.
, Wijns
, W.
, Windecker
, S.
, Clement
, D. L.
, Gillebert
, T. C.
, Rosei
, E. A.
, Anker
, S. D.
, Bauersachs
, J.
, Hitij
, J. B.
, Caulfield
, M.
, De Buyzere
, M.
, De Geest
, S.
, Derumeaux
, G. A.
, Erdine
, S.
, Farsang
, C.
, Funck-Brentano
, C.
, Gerc
, V.
, Germano
, G.
, Gielen
, S.
, Haller
, H.
, Jordan
, J.
, Kahan
, T.
, Komajda
, M.
, Lovic
, D.
, Mahrholdt
, H.
, Ostergren
, J.
, Parati
, G.
, Perk
, J.
, Polonia
, J.
, Popescu
, B. A.
, Reiner
, Z.
, Rydén
, L.
, Sirenko
, Y.
, Stanton
, A.
, Struijker-Boudier
, H.
, Vlachopoulos
, C.
, Volpe
, M.
, and Wood
, D. A.
, 2013
, “2013 ESH/ESC Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
,” Eur. Heart J.
, 34
(28
), pp. 2159
–2219
.10.
Meaume
, S.
, Benetos
, A.
, Henry
, O. F.
, Rudnichi
, A.
, and Safar
, M. E.
, 2001
, “Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Subjects >70 Years of Age
,” Arterioscler., Thromb., Vasc. Biol.
, 21
(12
), pp. 2046
–2050
.11.
Lehmann
, E. D.
, Gosling
, R. G.
, Fatemi-Langroudi
, B.
, and Taylor
, M. G.
, 1992
, “Non-Invasive Doppler Ultrasound Technique for the In Vivo Assessment of Aortic Compliance
,” J. Biomed. Eng.
, 14
(3
), pp. 250
–256
.12.
Jatoi
, N. A.
, Mahmud
, A.
, Bennett
, K.
, and Feely
, J.
, 2009
, “Assessment of Arterial Stiffness in Hypertension: Comparison of Oscillometric (Arteriograph), Piezoelectronic (Complior) and Tonometric (SphygmoCor) Techniques
,” J. Hypertens.
, 27
(11
), pp. 2186
–2191
.13.
Nam
, D. H.
, Lee
, W. B.
, Hong
, Y. S.
, and Lee
, S. S.
, 2013
, “Measurement of Spatial Pulse Wave Velocity by Using a Clip-Type Pulsimeter Equipped With a Hall Sensor and Photoplethysmography
,” Sensors
, 13
(4
), pp. 4714
–4723
.14.
Allen
, J.
, 2007
, “Photoplethysmography and Its Application in Clinical Physiological Measurement
,” Physiol. Meas.
, 28
(3
), p. R1.15.
Millikan
, G. A.
, 1942
, “The Oximeter, an Instrument for Measuring Continuously the Oxygen Saturation of Arterial Blood in Man
,” Rev. Sci. Instrum.
, 13
(10
), pp. 434
–444
.16.
Billauer
, E.
, 2012
, “Peakdet: Peak Detection Using MATLAB
,” Detect Peaks in a Vector, Billauer, E., Haifa, Israel, accessed July 20, 2012, http://billauer.co.il/peakdet.html17.
Corretti
, M. C.
, Anderson
, T. J.
, Benjamin
, E. J.
, Celermajer
, D.
, Charbonneau
, F.
, Creager
, M. A.
, Deanfield
, J.
, Drexler
, H.
, Gerhard-Herman
, M.
, Herrington
, D.
, Vallance
, P.
, Vita
, J.
, and Vogel
, R.
, 2002
, “Guidelines for the Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery: A Report of the International Brachial Artery Reactivity Task Force
,” J. Am. Coll. Cardiol.
, 39
(2
), pp. 257
–265
.Copyright © 2018 by ASME
You do not currently have access to this content.
