Photodynamic Therapy Mediated by Fullerenes and their Derivatives
3 Photochemistry and photophysics of fullerenyl molecular micelle and chromophore-fullerene conjugates
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Photoexcitation of C60 and fullerene derivatives induces a singlet fullerenyl excited state that is transformed to the corresponding triplet excited state, via intersystem energy crossing, with nearly quantitative efficiency . Subsequent energy transfer from the triplet fullerene derivatives to molecular oxygen produces singlet molecular oxygen in aerobic media. This photocatalytic effect becomes one of key mechanisms in photodynamic treatments using fullerene derivatives as photosensitizers. However, a high degree of functionalizaton on C60 for the enhancement of solubility and compatibility in biomedia resulted in a progressive decrease of the singlet oxygen production quantum yield [Φ (1O...