...Zhuochen Yuan; Cameron A. Czerpak; Michael Saheb Kashaf; Harry A. Quigley; Thao D. Nguyen This study measured the strain response to intraocular pressure (IOP) change in the sclera, choroid, and retina of glaucoma patients whose optic nerve head region was imaged by optical coherence tomography...

...Ning-Jiun Jan; Po-Yi Lee; Jacob Wallace; Michael Iasella; Alexandra Gogola; Bingrui Wang; Ian A. Sigal Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the sclera according to what is often called the process of recruitment. We recently reported experimental...

...Baptiste Coudrillier; Jacek Pijanka; Joan Jefferys; Thomas Sorensen; Harry A. Quigley; Craig Boote; Thao D. Nguyen The objective of this study was to measure the collagen fiber structure and estimate the material properties of 7 human donor scleras, from age 53 to 91. The specimens were subjected...

...Joseph T. Keyes; Dongmei Yan; Jacob H. Rader; Urs Utzinger; Jonathan P. Vande Geest The biomechanical model of glaucoma considers intraocular pressure-related stress and resultant strain on load bearing connective tissues of the optic nerve and surrounding peripapillary sclera as one major...

... with those found in human sclera are used, similar results are found. Experiments were conducted on 6 × 6 mm talc-sprinkled rubber specimens loaded using wire “rakes.” Points on a grid having 12 × 12 bays were tracked, and a detailed strain map was constructed. A finite element model based on the actual...

...Michaël J. A. Girard; J. Crawford Downs; Claude F. Burgoyne; J.-K. Francis Suh To experimentally characterize 2D surface mapping of the deformation pattern of porcine peripapillary sclera following acute elevations of intraocular pressure (IOP) from 5 mm Hg to 45 mm Hg . Four porcine eyes were...