... of the criterion at which a neuron dies is estimated. Unless the production rates of amyloid beta and tau monomers are very large, computations predict that for the accumulated toxicity to reach the critical value, the neural machinery responsible for the degradation of amyloid beta and tau monomers and aggregates...

...( a ) ). The author declares no competing interests. This article has no additional data. 14 07 2024 25 08 2024 03 10 2024 frontotemporal lobar degeneration TATA-binding protein-associated factor 15 prion-like domain protein aggregation neuron Finke−Watzky model...

.... , and Tomita , T. , 2022 , “ Mouse Models of Alzheimer's Disease ,” Front. Mol. Neurosci. , 15 , p. 912995 . 10.3389/fnmol.2022.912995 neuron Alzheimer's disease Finke−Watzky model mathematical modeling polymerization cube root hypothesis Division of Chemical...

... with peripheral motor and sensory neurons, such as type 2O Charcot-Marie-Tooth disease. We use two different models to simulate bidirectional transport in an axon: an anterograde-retrograde model, which neglects passive transport by diffusion in the cytosol, and a full slow transport model, which includes passive...

... Disease Research ,” Neuron , 52 ( 1 ), pp. 3 – 13 . 10.1016/j.neuron.2006.09.016 [2] Maqbool , M. , Mobashir , M. , and Hoda , N. , 2016 , “ Pivotal Role of Glycogen Synthase Kinase-3: A Therapeutic Target for Alzheimer's Disease ,” Eur. J. Med. Chem. , 107 , pp. 63 – 81...