... and trajectories of contiguous protein bolus volumes revealed that flow pulsation was beneficial at bolus break-up and that additional local wall curvature-based geometry irregularities also were. Using certain measures, local solute peak concentration blend-down appeared to be diffusion-dominated even for high...

...Gabi Schwartz; Andy Morejon; Thomas M. Best; Alicia R. Jackson; Francesco Travascio Due to lack of full vascularization, the meniscus relies on diffusion through the extracellular matrix to deliver small (e.g., nutrients) and large (e.g., proteins) to resident cells. Under normal physiological...

.... In this study, we present a computational finite element model (FEM) of solute transport through the synovium validated by experiments on synovial explants. Unsteady diffusion of urea, a small uncharged molecule, was measured through devitalized porcine and human synovium using custom-built diffusion chambers...

...Chris D. DiDomenico; Lawrence J. Bonassar Molecular transport of osteoarthritis (OA) therapeutics within articular cartilage is influenced by many factors, such as solute charge, that have yet to be fully understood. This study characterizes how solute charge influences local diffusion...

... and metabolite levels were measured in the peripheral skeletal muscle, normal myocardium, the infarct border zone, and the infarct interior. The diffusion coefficients of fluorescein or FITC-labeled dextran (0.3–70 kD) were measured in these tissues using fluorescence recovery after photobleaching. The vascular...

... and established mathematical transport models. Results demonstrate how the bridged μ Lane system was used to generate spatial concentration gradients that resulted in an experimentally measured Dextran diffusivity of ( 0.82 ± 0.01 ) × 10 − 6 cm 2 / s . System fabrication was performed via three different...

... conditions were continuities of mass and mass flux. Two parameters were defined to characterize the mass transports in the fluid and porous regions. The porous Damkohler number is the ratio of consumption to diffusion of the substrates in the porous medium. The fluid Damkohler number is the ratio...

... the transportation of oxygen in the brain tissue is mainly driven by a diffusion process caused by a concentration gradient of oxygen from blood to cells, the spatial organization of the vascular system, in which the oxygen content is higher than in tissue, is a key factor for maintaining effective transportation...

... that quantifies the influence of convection and diffusion on contrast transport. Optimized parameters were correlated with the intraneurysmal mean kinetic energy measured by PIV in the same aneurysm model. A strong correlation was observed between the convection and diffusion time constants and the mean kinetic...

... with the chondrocyte must pass through the pericellular environment. A quantitative understanding of the diffusional properties of the PCM may help in elucidating the regulatory role of the PCM in controlling transport to and from the chondrocyte. The diffusivities of fluorescently labeled 70 kDa and 500 kDa dextrans...

...Rosaire Mongrain; Isam Faik; Richard L. Leask; Josep Rodés-Cabau; Éric Larose; Olivier F. Bertrand In the context of drug eluting stent, we present two-dimensional numerical models of mass transport of the drug in the wall and in the lumen to study the effect of the drug diffusion coefficients...

... . Rice , J. R. , and Cleary , M. P. , 1976 , “ Some Basic Stress-Diffusion Solutions for Fluid-Saturated Elastic Porous Media...

... over a simple model with an open annular space. Overall, dispersion is > 10 3 times simple molecular diffusion. The result of enhanced dispersion is rapid spread and dilution of the bolus, effectively stirred by fluid movement around the fine structure. Loth , F. , Yardimci , M...

... presented. This mathematical model takes into account the ionic species diffusion, electric potential coupling, and large mechanical deformation. In addition, a correlation between the diffusive hydrogen ions and fixed-charge groups on the hydrogel polymeric chains is established based on the Langmuir...

... of motors with which the organelles are associated, and the mechanical properties of the cytoplasm. This paper presents a study that characterizes the diffusive motion of mitochondria in chondrocytes seeded in agarose constructs and what this implies about the mechanical properties of the cytoplasm. Method...

... approach was adopted to describe diffusion and uptake in the experimental model. Numerical predictions of lactate, based on simple relations for cell metabolism, were found to agree well for low glucose, but not for high glucose medium. Oxygen did not play a role in either case. Given the close association...

... is substituted into Eq. (5 a ), thus linearizing the equation and allowing an implicit differencing scheme. The spatial increment, Δ x = D Δ t / 2 , is one-half of the characteristic diffusion length, so that the mesh will automatically be fine enough to resolve diffusional processes...