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Journal Articles

An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels

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Alex Khang, Kenneth Meyer, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2023, 145(12): 121005.
Paper No: BIO-23-1085
https://doi.org/10.1115/1.4063436
Published Online: October 23, 2023
View Articletitled, An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels
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Topics: Fibers, Hydrogels, Modeling, Stress, Valves
Includes: Supplementary data
Journal Articles

An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation

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Gozde Basara, Gokhan Bahcecioglu, Xiang Ren, Pinar Zorlutuna
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2023, 145(8): 081004.
Paper No: BIO-22-1304
https://doi.org/10.1115/1.4062736
Published Online: June 21, 2023
View Articletitled, An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation
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Topics: Biological tissues, Computer simulation, Deformation, Gelatin, Proteins, Relaxation (Physics), Synchronization, Transients (Dynamics), Hydrogels
Includes: Supplementary data
Journal Articles

Viscoelastic Properties of Bioprinted Alginate Microbeads Compared to Their Bulk Hydrogel Analogs

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Cassandra L. Roberge, David M. Kingsley, Lexie R. Cornely, Connor J. Spain, Aiyana G. Fortin, David T. Corr
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031002.
Paper No: BIO-22-1157
https://doi.org/10.1115/1.4055757
Published Online: December 5, 2022
View Articletitled, Viscoelastic Properties of Bioprinted Alginate Microbeads Compared to Their Bulk Hydrogel Analogs
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Topics: Compression, Hydrogels, Stress, Bioprinting, Relaxation (Physics), Diffusion (Physics), Viscoelasticity
Includes: Supplementary data
Journal Articles

The Construction of Biologically Relevant Fiber-Reinforced Hydrogel Geometries Using Air-Assisted Dual-Polarity Electrospinning

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James F. Nowak, Andrew Kerns, Priyank Patel, Kate Batzinger, Xing Tong, Johnson Samuel
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011009.
Paper No: BIO-22-1086
https://doi.org/10.1115/1.4055038
Published Online: August 19, 2022
View Articletitled, The Construction of Biologically Relevant Fiber-Reinforced Hydrogel Geometries Using Air-Assisted Dual-Polarity Electrospinning
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Topics: Electrospinning, Fibers, Hydrogels
Includes: Supplementary data
Journal Articles

Optimization of Oxygen Delivery Within Hydrogels

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Sophia M. Mavris, Laura M. Hansen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2021, 143(10): 101004.
Paper No: BIO-21-1045
https://doi.org/10.1115/1.4051119
Published Online: June 16, 2021
View Articletitled, Optimization of Oxygen Delivery Within Hydrogels
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Topics: Hydrogels, Oxygen, Diffusion (Physics)
Journal Articles

A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs

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Sophia Leung, Jung-Joo Kim, David S. Musson, Sue R. McGlashan, Jillian Cornish, Iain Anderson, Vickie B. K. Shim
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2021, 143(8): 084503.
Paper No: BIO-20-1362
https://doi.org/10.1115/1.4051116
Published Online: June 16, 2021
View Articletitled, A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs
Open the PDF for A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs in another window
Topics: Chondrocytes, Compression, Design, Hydrogels, Shear (Mechanics), Stress, Deformation, Agar, Tension
Includes: Supplementary data
Journal Articles

On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction

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Alex Khang, Emma Lejeune, Ali Abbaspour, Daniel P. Howsmon, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. September 2021, 143(9): 094503.
Paper No: BIO-21-1009
https://doi.org/10.1115/1.4050915
Published Online: May 18, 2021
View Articletitled, On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction
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Topics: Shapes, Valves, Hydrogels
Journal Articles

Recovery of Tractions Exerted by Single Cells in Three-Dimensional Nonlinear Matrices

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Dawei Song, Li Dong, Mukund Gupta, Linqing Li, Ottmar Klaas, Adrian Loghin, Mark Beall, Christopher S. Chen, Assad A. Oberai
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2020, 142(8): 081012.
Paper No: BIO-19-1547
https://doi.org/10.1115/1.4046974
Published Online: July 6, 2020
View Articletitled, Recovery of Tractions Exerted by Single Cells in Three-Dimensional Nonlinear Matrices
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Topics: Displacement, Hydrogels, Traction, Noise (Sound), Errors, Inverse problems, Algorithms
Journal Articles

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks

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Michelle A. Cruz, Steven McAnany, Nikita Gupta, Rose G. Long, Philip Nasser, David Eglin, Andrew C. Hecht, Svenja Illien-Junger, James C. Iatridis
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2017, 139(8): 084501.
Paper No: BIO-16-1241
https://doi.org/10.1115/1.4036623
Published Online: June 7, 2017
View Articletitled, Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks
Open the PDF for Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks in another window
Topics: Adhesives, Annulus, Fibers, Intervertebral discs, Maintenance, Biomechanics, Materials properties, Density, Electron microscopy, Shear modulus
Includes: Supplementary data
Journal Articles

Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair

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Rose G. Long, Olivia M. Torre, Warren W. Hom, Dylan J. Assael, James C. Iatridis
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2016, 138(2): 021007.
Paper No: BIO-15-1421
https://doi.org/10.1115/1.4032353
Published Online: January 27, 2016
View Articletitled, Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair
Open the PDF for Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair in another window
Topics: Biological tissues, Biomaterials, Design, Hydrogels, Maintenance, Materials properties, Shear (Mechanics), Testing, Annulus, Pressure
Includes: Supplementary data
Journal Articles

Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel

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Matthew G. Ondeck, Adam J. Engler
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2016, 138(2): 021003.
Paper No: BIO-15-1566
https://doi.org/10.1115/1.4032429
Published Online: January 27, 2016
View Articletitled, Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel
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Topics: Hydrogels, Stiffness, Ultraviolet radiation, Fibroblasts, Polymers, Polymerization, Atomic force microscopy
Includes: Supplementary data
Journal Articles

Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery

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Brent L. Showalter, Dawn M. Elliott, Weiliam Chen, Neil R. Malhotra
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2015, 137(8): 081008.
Paper No: BIO-14-1334
https://doi.org/10.1115/1.4030530
Published Online: August 1, 2015
View Articletitled, Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery
Open the PDF for Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery in another window
Topics: Disks, Hydrogels, Mechanical testing, Physiology, Cycles, Compression, Testing
Journal Articles

Nucleus Implantation: The Biomechanics of Augmentation Versus Replacement With Varying Degrees of Nucleotomy

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Marco Cannella, Jessica L. Isaacs, Shanee Allen, Argjenta Orana, Edward Vresilovic, Michele Marcolongo
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2014, 136(5): 051001.
Paper No: BIO-13-1212
https://doi.org/10.1115/1.4027056
Published Online: April 10, 2014
View Articletitled, Nucleus Implantation: The Biomechanics of Augmentation Versus Replacement With Varying Degrees of Nucleotomy
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Topics: Biomechanics, Disks, Hydrogels, Pressure, Stiffness
Journal Articles

A Phase Field Approach for Multicellular Aggregate Fusion in Biofabrication

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Xiaofeng Yang, Yi Sun, Qi Wang
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2013, 135(7): 071005.
Paper No: BIO-13-1062
https://doi.org/10.1115/1.4024139
Published Online: June 11, 2013
View Articletitled, A Phase Field Approach for Multicellular Aggregate Fusion in Biofabrication
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Topics: Biological tissues, Blood vessels, Fluids, Hydrogels, Simulation, Surface mount components, Blood, Bioprinting, Engineering simulation
Journal Articles

The Use of a Novel Injectable Hydrogel Nucleus Pulposus Replacement in Restoring the Mechanical Properties of Cyclically Fatigued Porcine Intervertebral Discs

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Christian Balkovec, Jennifer Vernengo, Stuart M. McGill
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2013, 135(6): 061004.
Paper No: BIO-12-1270
https://doi.org/10.1115/1.4024285
Published Online: May 9, 2013
View Articletitled, The Use of a Novel Injectable Hydrogel Nucleus Pulposus Replacement in Restoring the Mechanical Properties of Cyclically Fatigued Porcine Intervertebral Discs
Open the PDF for The Use of a Novel Injectable Hydrogel Nucleus Pulposus Replacement in Restoring the Mechanical Properties of Cyclically Fatigued Porcine Intervertebral Discs in another window
Topics: Hydrogels, Intervertebral discs, Disks, Stiffness, Mechanical properties, Testing
Journal Articles

Influence of Needle Insertion Speed on Backflow for Convection-Enhanced Delivery

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Fernando Casanova, Paul R. Carney, Malisa Sarntinoranont
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2012, 134(4): 041006.
https://doi.org/10.1115/1.4006404
Published Online: April 26, 2012
View Articletitled, Influence of Needle Insertion Speed on Backflow for Convection-Enhanced Delivery
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Topics: Biological tissues, Hydrogels, Needles, Damage, Brain, Convection, Flow (Dynamics)
Journal Articles

A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation

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Taly P. Appelman, Joseph Mizrahi, Dror Seliktar
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2011, 133(4): 041010.
https://doi.org/10.1115/1.4003314
Published Online: March 23, 2011
View Articletitled, A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation
Open the PDF for A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation in another window
Topics: Cartilage, Chondrocytes, Deformation, Engineering simulation, Finite element model, Hydrogels, Simulation, Stress, Finite element analysis, Biological tissues
Journal Articles

A Large Strain Material Model for Soft Tissues With Functionally Graded Properties

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Uwe-Jens Görke, Hubert Günther, Thomas Nagel, Markus A. Wimmer
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2010, 132(7): 074502.
https://doi.org/10.1115/1.4001312
Published Online: June 2, 2010
View Articletitled, A Large Strain Material Model for Soft Tissues With Functionally Graded Properties
Open the PDF for A Large Strain Material Model for Soft Tissues With Functionally Graded Properties in another window
Topics: Anisotropy, Biological tissues, Cartilage, Compression, Deformation, Finite element analysis, Hydrogels, Soft tissues, Stress, Fibers
Journal Articles

Poro-Viscoelastic Behavior of Gelatin Hydrogels Under Compression-Implications for Bioelasticity Imaging

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Sureshkumar Kalyanam, Rebecca D. Yapp, Michael F. Insana
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2009, 131(8): 081005.
https://doi.org/10.1115/1.3127250
Published Online: July 2, 2009
View Articletitled, Poro-Viscoelastic Behavior of Gelatin Hydrogels Under Compression-Implications for Bioelasticity Imaging
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Topics: Compression, Finite element analysis, Hydrogels, Relaxation (Physics), Stress, Fluids, Gelatin, Creep, Deformation, Imaging
Journal Articles

Development of a Three-Dimensional Bioprinter: Construction of Cell Supporting Structures Using Hydrogel and State-Of-The-Art Inkjet Technology

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Yuichi Nishiyama, Makoto Nakamura, Chizuka Henmi, Kumiko Yamaguchi, Shuichi Mochizuki, Hidemoto Nakagawa, Koki Takiura
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Design Innovations
J Biomech Eng. March 2009, 131(3): 035001.
https://doi.org/10.1115/1.3002759
Published Online: December 31, 2008
View Articletitled, Development of a Three-Dimensional Bioprinter: Construction of Cell Supporting Structures Using Hydrogel and State-Of-The-Art Inkjet Technology
Open the PDF for Development of a Three-Dimensional Bioprinter: Construction of Cell Supporting Structures Using Hydrogel and State-Of-The-Art Inkjet Technology in another window
Topics: Construction, Hydrogels, Manufacturing, Nozzles, Viscosity, Sodium, Printing, Biocompatibility, Biological cells