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Journal Articles

Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit

Open Access
Zinan Hu, Jessica E. Herrmann, Erica L. Schwarz, Fannie M. Gerosa, Nir Emuna, Jay D. Humphrey, Adam W. Feinberg, Tain-Yen Hsia, Mark A. Skylar-Scott, Alison L. Marsden
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2025, 147(7): 071001.
Paper No: BIO-24-1237
https://doi.org/10.1115/1.4068319
Published Online: May 15, 2025
View Articletitled, Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit
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Topics: Bioprinting, Design, Electrophysiology, Fibers, Liver, Pressure, Simulation, Tension, Valves, Fluids
Journal Articles

Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors

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Accepted Manuscript
Yuankai Lu, Yi Hua, Po-Yi Lee, Andrew Theophanous, Shaharoz Tahir, Qi Tian, Ian A. Sigal
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng.
Paper No: BIO-24-1228
https://doi.org/10.1115/1.4068577
Published Online: May 2, 2025
View Articletitled, Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors
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Topics: Anatomy, Biological tissues, Blood flow, Damage, Hemodynamics, Modeling, Oxygen, Physiology, Pressure, Risk
Journal Articles

Hemodynamic Evaluation of Norwood Aortic Arch Geometry Compared to Native Arch Controls

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Aloma Blanch-Granada, John F. LaDisa, Jr., Margaret M. Samyn, Joseph R. Cava, Stephanie S. Handler, Jennifer F Gerardin, Benjamin Goot, Mehdi Maadooliat, Viktor Hraška
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2025, 147(5): 051003.
Paper No: BIO-24-1224
https://doi.org/10.1115/1.4068009
Published Online: March 21, 2025
View Articletitled, Hemodynamic Evaluation of Norwood Aortic Arch Geometry Compared to Native Arch Controls
Open the PDF for Hemodynamic Evaluation of Norwood Aortic Arch Geometry Compared to Native Arch Controls in another window
Topics: Aorta, Aortic arch, Arches, Blood flow, Engineering simulation, Geometry, Hemodynamics, Shear stress, Simulation, Computational fluid dynamics
Includes: Supplementary data
Journal Articles

Influence of Geometric Parameters on the Hemodynamic Characteristics of the Vertebral Artery

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Yanlu Chen, Yuzhou Cheng, Kun Luo, Jianren Fan
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2025, 147(3): 031005.
Paper No: BIO-24-1233
https://doi.org/10.1115/1.4067578
Published Online: January 28, 2025
View Articletitled, Influence of Geometric Parameters on the Hemodynamic Characteristics of the Vertebral Artery
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Topics: Hemodynamics, Flow (Dynamics), Bifurcation, Atherosclerosis, Blood, Helicity, Blood flow
Journal Articles

Influence of Left Subclavian Artery Stent Graft Geometry on Blood Hemodynamics in Thoracic Endovascular Aortic Repair

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Song Xue, Tiandong Lu, Wenqing Hu, Zeyang Xia, Jun Zhang, Xinwu Lu, Jing Xiong
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2025, 147(2): 021008.
Paper No: BIO-24-1154
https://doi.org/10.1115/1.4067448
Published Online: January 3, 2025
View Articletitled, Influence of Left Subclavian Artery Stent Graft Geometry on Blood Hemodynamics in Thoracic Endovascular Aortic Repair
Open the PDF for Influence of Left Subclavian Artery Stent Graft Geometry on Blood Hemodynamics in Thoracic Endovascular Aortic Repair in another window
Topics: Blood, Blood flow, Flow (Dynamics), Geometry, Hemodynamics, Maintenance, Stents, Vortices, Aortic arch, Boundary-value problems
Journal Articles

Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps

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Navideh Abbasnezhad, Farid Bakir
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2025, 147(2): 021001.
Paper No: BIO-24-1005
https://doi.org/10.1115/1.4067009
Published Online: November 27, 2024
View Articletitled, Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps
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Topics: Blood, Computational fluid dynamics, Fluids, Pumps, Shear stress, Blades, Impellers, Flow (Dynamics), Hemodynamics, Simulation
Journal Articles

Computational Study on the Effects of Valve Orientation on the Hemodynamics and Leaflet Dynamics of Bioprosthetic Pulmonary Valves

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Kwang Bem Ko, Jung-Hee Seo, Ashish Doshi, Danielle Gottlieb Sen, Rajat Mittal
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2024, 146(12): 121002.
Paper No: BIO-24-1133
https://doi.org/10.1115/1.4066178
Published Online: September 6, 2024
View Articletitled, Computational Study on the Effects of Valve Orientation on the Hemodynamics and Leaflet Dynamics of Bioprosthetic Pulmonary Valves
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Topics: Valves, Flow (Dynamics), Hemodynamics, Pulmonary artery, Pressure
Journal Articles

Vascular Remodeling During Late-Gestation Pregnancy: An In-Vitro Assessment of the Murine Ascending Thoracic Aorta

Open Access
Ana I. Vargas, Samar A. Tarraf, Turner Jennings, Chiara Bellini, Rouzbeh Amini
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2024, 146(7): 071004.
Paper No: BIO-23-1351
https://doi.org/10.1115/1.4064744
Published Online: March 19, 2024
View Articletitled, Vascular Remodeling During Late-Gestation Pregnancy: An In-Vitro Assessment of the Murine Ascending Thoracic Aorta
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Topics: Aorta, Biological tissues, Blood, Hemodynamics, Pressure, Stiffness, Stress, Biomechanics, Wall thickness, Physiology
Journal Articles

An In Silico Model for Predicting the Efficacy of Edge-to-Edge Repair for Mitral Regurgitation

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Junichi Ooida, Naoki Kiyohara, Hironaga Noguchi, Yuichiro Oguchi, Kohei Nagane, Takuya Sakaguchi, Gakuto Aoyama, Fumimasa Shige, James V. Chapman, Masahiko Asami, Klaus Fuglsang Kofoed, Michael Huy Cuong Pham, Koshiro Suzuki
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2024, 146(2): 021004.
Paper No: BIO-23-1176
https://doi.org/10.1115/1.4064055
Published Online: December 12, 2023
View Articletitled, An In Silico Model for Predicting the Efficacy of Edge-to-Edge Repair for Mitral Regurgitation
Open the PDF for An In Silico Model for Predicting the Efficacy of Edge-to-Edge Repair for Mitral Regurgitation in another window
Topics: Deformation, Hemodynamics, Simulation, Valves, Maintenance, Optimization, Pressure
Journal Articles

Using a Mock Circulatory Loop as a Regulatory Science Tool to Simulate Different Heart Failure Conditions

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Gavin A. D'Souza, Jean E. Rinaldi, Moustafa Meki, Annabelle Crusan, Eric Richardson, Meir Shinnar, Luke H. Herbertson
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2024, 146(1): 011004.
Paper No: BIO-23-1170
https://doi.org/10.1115/1.4063746
Published Online: November 3, 2023
View Articletitled, Using a Mock Circulatory Loop as a Regulatory Science Tool to Simulate Different Heart Failure Conditions
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Topics: Fluids, Heart failure, Hemodynamics, Pressure, Testing, Valves, Flow (Dynamics), Diseases, Testing equipment, Cardiovascular system
Journal Articles

Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support

Open Access
Vi Vu, Lorenzo Rossini, Juan C. del Alamo, Walter Dembitsky, Richard A. Gray, Karen May-Newman
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2023, 145(11): 111010.
Paper No: BIO-23-1013
https://doi.org/10.1115/1.4063147
Published Online: September 4, 2023
View Articletitled, Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support
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Topics: Flow (Dynamics), Heart failure, Valves, Ventricular assist devices, Vortices, Blood, Hemodynamics, Shear (Mechanics), Fluids
Includes: Supplementary data
Journal Articles

Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease

Free
Hannah L. Cebull, Olukayode O. Aremu, Radhika S. Kulkarni, Samuel X. Zhang, Petronella Samuels, Stephen Jermy, Ntobeko A.B. Ntusi, Craig J. Goergen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2023, 145(11): 111003.
Paper No: BIO-23-1101
https://doi.org/10.1115/1.4063000
Published Online: August 2, 2023
View Articletitled, Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease
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Topics: Aorta, Blood flow, Computational fluid dynamics, Diseases, Flow (Dynamics), Hemodynamics, Shear (Mechanics), Shear stress, Simulation, Statistical analysis
Includes: Supplementary data
Journal Articles

A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants

Free
Ashley A. Hiebing, Riley G. Pieper, Colleen M. Witzenburg
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2023, 145(10): 101007.
Paper No: BIO-22-1295
https://doi.org/10.1115/1.4062779
Published Online: July 14, 2023
View Articletitled, A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants
Open the PDF for A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants in another window
Topics: Aorta, Blood, Computer simulation, Dimensions, Hemodynamics, Pressure, Simulation, Weight (Mass)
Includes: Supplementary data
Journal Articles

A Computational Study of Dynamic Obstruction in Type B Aortic Dissection

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T. Kim, P. A. J. van Bakel, N. Nama, N. Burris, H. J. Patel, D. M. Williams, C. A. Figueroa
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031008.
Paper No: BIO-22-1176
https://doi.org/10.1115/1.4056355
Published Online: December 21, 2022
View Articletitled, A Computational Study of Dynamic Obstruction in Type B Aortic Dissection
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Topics: Blood, Flow (Dynamics), Pressure, Simulation, Displacement, Hemodynamics, Vessels, Aorta, Boundary-value problems
Journal Articles

svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies

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Jonathan Pham, Sofia Wyetzner, Martin R. Pfaller, David W. Parker, Doug L. James, Alison L. Marsden
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031001.
Paper No: BIO-22-1143
https://doi.org/10.1115/1.4056055
Published Online: December 5, 2022
View Articletitled, svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies
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Topics: Aneurysms, Engineering simulation, Geometry, Hemodynamics, Shapes, Simulation, Deformation, Aorta, Computational fluid dynamics, Modeling
Journal Articles

Reducing Geometric Uncertainty in Computational Hemodynamics by Deep Learning-Assisted Parallel-Chain MCMC

Free
Pan Du, Jian-Xun Wang
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2022, 144(12): 121009.
Paper No: BIO-22-1104
https://doi.org/10.1115/1.4055809
Published Online: October 17, 2022
View Articletitled, Reducing Geometric Uncertainty in Computational Hemodynamics by Deep Learning-Assisted Parallel-Chain MCMC
Open the PDF for Reducing Geometric Uncertainty in Computational Hemodynamics by Deep Learning-Assisted Parallel-Chain MCMC in another window
Topics: Algorithms, Aorta, Chain, Computational fluid dynamics, Flow (Dynamics), Hemodynamics, Modeling, Simulation, Uncertainty, Artificial neural networks
Journal Articles

Quantifying the Effect of Body Habitus on Cardiac Auscultation Via Computational Hemoacoustics

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David Hojun Lee, Jung-Hee Seo, Rajat Mittal
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2023, 145(2): 024503.
Paper No: BIO-22-1165
https://doi.org/10.1115/1.4055513
Published Online: October 6, 2022
View Articletitled, Quantifying the Effect of Body Habitus on Cardiac Auscultation Via Computational Hemoacoustics
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Topics: Blood flow, Elastic waves, Emission spectroscopy, Hemodynamics, Signals, Simulation, Spectroscopy, Valves, Computational methods, Modeling
Journal Articles

Influence of the Anatomical Structure on the Hemodynamics of Iliac Vein Stenosis

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Li Changsheng, Feng Haiquan, Wang Kun, Wang Xiaotian, Wang Yonggang
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011013.
Paper No: BIO-21-1445
https://doi.org/10.1115/1.4055307
Published Online: September 19, 2022
View Articletitled, Influence of the Anatomical Structure on the Hemodynamics of Iliac Vein Stenosis
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Topics: Blood flow, Hemodynamics, Particulate matter, Shear stress, Vessels, Shear (Mechanics), Blood vessels, Flow (Dynamics), Computational fluid dynamics, Thrombosis
Journal Articles

Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms

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Christian J. Mandrycky, Ashley N. Abel, Samuel Levy, Laurel M. Marsh, Fanette Chassagne, Venkat K. Chivukula, Sari E. Barczay, Cory M. Kelly, Louis J. Kim, Alberto Aliseda, Michael R. Levitt, Ying Zheng
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011001.
Paper No: BIO-21-1298
https://doi.org/10.1115/1.4054981
Published Online: August 19, 2022
View Articletitled, Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms
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Topics: Aneurysms, Computational fluid dynamics, Endothelial cells, Flow (Dynamics), Hemodynamics, Proteins, Vessels, Polarization (Electricity), Polarization (Light), Polarization (Waves)
Includes: Supplementary data
Journal Articles

Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure

Free
Yuanjia Zhu, Robert J. Wilkerson, Pearly K. Pandya, Danielle M. Mullis, Catherine A. Wu, Sarah Madira, Mateo Marin-Cuartas, Matthew H. Park, Annabel M. Imbrie-Moore, Y. Joseph Woo
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011005.
Paper No: BIO-22-1027
https://doi.org/10.1115/1.4055033
Published Online: August 19, 2022
View Articletitled, Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure
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Topics: Flow (Dynamics), Hemodynamics, Kinematics, Valves, Flutter (Aerodynamics)
Includes: Supplementary data