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Journal Articles

Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms

Christian J. Mandrycky, Ashley N. Abel, Samuel Levy, Laurel M. Marsh, Fanette Chassagne, Venkat K. Chivukula, Sari E. Barczay, Cory M. Kelly, Louis J. Kim, Alberto Aliseda, Michael R. Levitt, Ying Zheng
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011001.
Paper No: BIO-21-1298
https://doi.org/10.1115/1.4054981
Published Online: August 19, 2022
View Article titled, Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms
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Topics: Aneurysms, Computational fluid dynamics, Endothelial cells, Flow (Dynamics), Hemodynamics, Proteins, Vessels, Polarization (Electricity), Polarization (Light), Polarization (Waves)
Includes: Supplementary data
Journal Articles

Effect of Human Synovial Fluid From Osteoarthritis Patients and Healthy Individuals on Lymphatic Contractile Activity

Eleftheria Michalaki, Zhanna Nepiyushchikh, Josephine M. Rudd, Fabrice C. Bernard, Anish Mukherjee, Jay M. McKinney, Thanh N. Doan, Nick J. Willett, J. Brandon Dixon
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2022, 144(7): 071012.
Paper No: BIO-21-1020
https://doi.org/10.1115/1.4053749
Published Online: February 24, 2022
View Article titled, Effect of Human Synovial Fluid From Osteoarthritis Patients and Healthy Individuals on Lymphatic Contractile Activity
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Topics: Fluids, Osteoarthritis, Vessels, Endothelial cells
Includes: Supplementary data
Journal Articles

The Story of Wall Shear Stress in Coronary Artery Atherosclerosis: Biochemical Transport and Mechanotransduction

Mostafa Mahmoudi, Ali Farghadan, Daniel R. McConnell, Alex J. Barker, Jolanda J. Wentzel, Matthew J. Budoff, Amirhossein Arzani
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2021, 143(4): 041002.
Paper No: BIO-20-1283
https://doi.org/10.1115/1.4049026
Published Online: December 14, 2020
View Article titled, The Story of Wall Shear Stress in Coronary Artery Atherosclerosis: Biochemical Transport and Mechanotransduction
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Topics: Atherosclerosis, Coronary arteries, Oxygen, Proteins, Shear stress, Density, Endothelial cells, Permeability, Diseases, Computational fluid dynamics
Journal Articles

Fiber Crimp Confers Matrix Mechanical Nonlinearity, Regulates Endothelial Cell Mechanosensing, and Promotes Microvascular Network Formation

Christopher D. Davidson, Danica Kristen P. Jayco, William Y. Wang, Ariella Shikanov, Brendon M. Baker
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2020, 142(11): 111009.
Paper No: BIO-20-1104
https://doi.org/10.1115/1.4048191
Published Online: September 11, 2020
View Article titled, Fiber Crimp Confers Matrix Mechanical Nonlinearity, Regulates Endothelial Cell Mechanosensing, and Promotes Microvascular Network Formation
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Topics: Endothelial cells, Fibers
Includes: Supplementary data
Journal Articles

Early-Stage Dynamics in Vascular Endothelial Cells Exposed to Hydrostatic Pressure

Daisuke Yoshino, Masaaki Sato
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2019, 141(9): 091006.
Paper No: BIO-19-1078
https://doi.org/10.1115/1.4044046
Published Online: August 2, 2019
View Article titled, Early-Stage Dynamics in Vascular Endothelial Cells Exposed to Hydrostatic Pressure
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Topics: Endothelial cells, Hydrostatic pressure, Pressure, Dynamics (Mechanics), Junctions, Water
Journal Articles

Quantification of Morphological Modulation, F-Actin Remodeling, and PECAM-1 (CD-31) Redistribution in Endothelial Cells in Response to Fluid-Induced Shear Stress Under Various Flow Conditions

Hamed Avari, Kem A. Rogers, Eric Savory
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2019, 141(4): 041004.
Paper No: BIO-17-1598
https://doi.org/10.1115/1.4042601
Published Online: February 15, 2019
View Article titled, Quantification of Morphological Modulation, F-Actin Remodeling, and PECAM-1 (CD-31) Redistribution in Endothelial Cells in Response to Fluid-Induced Shear Stress Under Various Flow Conditions
Open the PDF for Quantification of Morphological Modulation, F-Actin Remodeling, and PECAM-1 (CD-31) Redistribution in Endothelial Cells in Response to Fluid-Induced Shear Stress Under Various Flow Conditions in another window
Topics: Endothelial cells, Flow (Dynamics), Shear stress, Adhesion
Journal Articles

Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration

Numpong Punyaratabandhu, Pimkhwan Kongoup, Panadda Dechadilok, Pisut Katavetin, Wannapong Triampo
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2017, 139(12): 121005.
Paper No: BIO-17-1062
https://doi.org/10.1115/1.4037550
Published Online: September 28, 2017
View Article titled, Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
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Topics: Cylinders, Endothelial cells, Fibers, Fluids, Macromolecules, Permeability, Diaphragms (Mechanical devices), Diaphragms (Structural), Filtration, Physiology
Journal Articles

Study of Cholesterol Repletion Effect on Nanomechanical Properties of Human Umbilical Vein Endothelial Cell Via Rapid Broadband Atomic Force Microscopy

Bo Yan, Juan Ren, Yue Liu, Huarong Huang, Xi Zheng, Qingze Zou
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. March 2017, 139(3): 034501.
Paper No: BIO-15-1627
https://doi.org/10.1115/1.4035260
Published Online: January 23, 2017
View Article titled, Study of Cholesterol Repletion Effect on Nanomechanical Properties of Human Umbilical Vein Endothelial Cell Via Rapid Broadband Atomic Force Microscopy
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Topics: Atomic force microscopy, Endothelial cells, Excitation, Young's modulus, Oscillations, Cell membranes, Elasticity, Viscoelasticity, Mechanical properties
Journal Articles

Engineered Microvessels for the Study of Human Disease

Samuel G. Rayner, Ying Zheng
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. November 2016, 138(11): 110801.
Paper No: BIO-16-1222
https://doi.org/10.1115/1.4034428
Published Online: October 21, 2016
View Article titled, Engineered Microvessels for the Study of Human Disease
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Topics: Blood, Diseases, Endothelial cells, Vessels, Flow (Dynamics), Biological tissues, Biology, Tumors, Physiology, Permeability
Journal Articles

2014 Editors' Choice Papers

Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Editorial
J Biomech Eng. February 2015, 137(2): 020206.
Paper No: BIO-14-1597
https://doi.org/10.1115/1.4029300
Published Online: February 1, 2015
View Article titled, 2014 Editors' Choice Papers
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Topics: Annulus, Anterior cruciate ligament, Biological tissues, Biomaterials, Biomechanical engineering, Bone, Deformation, Encryption, Endothelial cells, Freezing
Journal Articles

Glycated Collagen Decreased Endothelial Cell Fibronectin Alignment in Response to Cyclic Stretch Via Interruption of Actin Alignment

Dannielle S. Figueroa, Steven F. Kemeny, Alisa Morss Clyne
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2014, 136(10): 101010.
Paper No: BIO-14-1008
https://doi.org/10.1115/1.4028037
Published Online: August 12, 2014
View Article titled, Glycated Collagen Decreased Endothelial Cell Fibronectin Alignment in Response to Cyclic Stretch Via Interruption of Actin Alignment
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Topics: Endothelial cells, Fibers, Proteins
Journal Articles

Mechanical Interaction of Angiogenic Microvessels With the Extracellular Matrix

Lowell T. Edgar, James B. Hoying, Urs Utzinger, Clayton J. Underwood, Laxminarayanan Krishnan, Brenda K. Baggett, Steve A. Maas, James E. Guilkey, Jeffrey A. Weiss
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2014, 136(2): 021001.
Paper No: BIO-13-1503
https://doi.org/10.1115/1.4026471
Published Online: February 5, 2014
View Article titled, Mechanical Interaction of Angiogenic Microvessels With the Extracellular Matrix
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Topics: Boundary-value problems, Deformation, Density, Imaging, Simulation, Traction, Vessels, Photons, Computer simulation, Time series
Includes: Multimedia, Supplementary data
Journal Articles

Microscopic Matrix Remodeling Precedes Endothelial Morphological Changes During Capillary Morphogenesis

Claire McLeod, John Higgins, Yekaterina Miroshnikova, Rachel Liu, Aliesha Garrett, Alisha L. Sarang-Sieminski
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2013, 135(7): 071002.
Paper No: BIO-12-1453
https://doi.org/10.1115/1.4023984
Published Online: June 11, 2013
View Article titled, Microscopic Matrix Remodeling Precedes Endothelial Morphological Changes During Capillary Morphogenesis
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Topics: Compacting, Endothelial cells, Fibers, Elongation, Visualization
Journal Articles

Endothelial Cell Morphologic Response to Asymmetric Stenosis Hemodynamics: Effects of Spatial Wall Shear Stress Gradients

Leonie Rouleau, Monica Farcas, Jean-Claude Tardif, Rosaire Mongrain, Richard L. Leask
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2010, 132(8): 081013.
https://doi.org/10.1115/1.4001891
Published Online: July 29, 2010
View Article titled, Endothelial Cell Morphologic Response to Asymmetric Stenosis Hemodynamics: Effects of Spatial Wall Shear Stress Gradients
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Topics: Endothelial cells, Flow (Dynamics), Hemodynamics, Shapes, Shear stress
Journal Articles

The Response of Human Aortic Endothelial Cells in a Stenotic Hemodynamic Environment: Effect of Duration, Magnitude, and Spatial Gradients in Wall Shear Stress

Leonie Rouleau, Joanna Rossi, Richard L. Leask
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. July 2010, 132(7): 071015.
https://doi.org/10.1115/1.4001217
Published Online: June 4, 2010
View Article titled, The Response of Human Aortic Endothelial Cells in a Stenotic Hemodynamic Environment: Effect of Duration, Magnitude, and Spatial Gradients in Wall Shear Stress
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Topics: Adhesion, Endothelial cells, Flow (Dynamics), Hemodynamics, Proteins, Shear stress, Microscopy
Journal Articles

Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?

Liang Ge, Fotis Sotiropoulos
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. January 2010, 132(1): 014505.
https://doi.org/10.1115/1.4000162
Published Online: December 9, 2009
View Article titled, Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?
Open the PDF for Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification? in another window
Topics: Blood flow, Flow (Dynamics), Hemodynamics, Shear stress, Valves, Endothelial cells
Journal Articles

A Two-Dimensional Computational Model of Lymph Transport Across Primary Lymphatic Valves

Peter Galie, Robert L. Spilker
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111004.
https://doi.org/10.1115/1.3212108
Published Online: October 16, 2009
View Article titled, A Two-Dimensional Computational Model of Lymph Transport Across Primary Lymphatic Valves
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Topics: Deflection, Endothelial cells, Flow (Dynamics), Fluids, Junctions, Pressure, Valves, Computation, Finite element analysis, Vessels
Journal Articles

Bioprinting Endothelial Cells With Alginate for 3D Tissue Constructs

Saif Khalil, Wei Sun
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111002.
https://doi.org/10.1115/1.3128729
Published Online: October 16, 2009
View Article titled, Bioprinting Endothelial Cells With Alginate for 3D Tissue Constructs
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Topics: Biological tissues, Bioprinting, Manufacturing, Disks, Sodium, Endothelial cells
Journal Articles

Bubble Motion in a Blood Vessel: Shear Stress Induced Endothelial Cell Injury

K. Mukundakrishnan, P. S. Ayyaswamy, D. M. Eckmann
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074516.
https://doi.org/10.1115/1.3153310
Published Online: July 7, 2009
View Article titled, Bubble Motion in a Blood Vessel: Shear Stress Induced Endothelial Cell Injury
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Topics: Blood vessels, Bubbles, Endothelial cells, Flow (Dynamics), Shear stress, Wounds, Vessels, Vortices, Shear (Mechanics)
Journal Articles

Effect of Me 2 SO on Membrane Phase Behavior and Protein Denaturation of Human Pulmonary Endothelial Cells Studied by In Situ FTIR Spectroscopy

Ralf Spindler, Willem F. Wolkers, Birgit Glasmacher
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074517.
https://doi.org/10.1115/1.3156802
Published Online: July 7, 2009
View Article titled, Effect of Me 2 SO on Membrane Phase Behavior and Protein Denaturation of Human Pulmonary Endothelial Cells Studied by In Situ FTIR Spectroscopy
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Topics: Fourier transform infrared spectroscopy, Membranes, Proteins, Stability, Temperature, Endothelial cells, Heating