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Journal Articles

Quantification of Cartilage Poroelastic Material Properties Via Analysis of Loading-Induced Cell Death

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Alexander Kotelsky, Joseph S. Carrier, Mark R. Buckley
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2024, 146(8): 081006.
Paper No: BIO-23-1178
https://doi.org/10.1115/1.4065194
Published Online: April 8, 2024
View Articletitled, Quantification of Cartilage Poroelastic Material Properties Via Analysis of Loading-Induced Cell Death
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Topics: Cartilage, Materials properties, Creep, Biological tissues, Stress, Finite element analysis, Chondrocytes
Includes: Supplementary data
Journal Articles

Biot Theory-Based Finite Element Modeling of Continuous Ultrasound Propagation Through Microscale Articular Cartilage

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Sattik Basu, Anu Subramanian, Sarma L. Rani
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2023, 145(5): 051002.
Paper No: BIO-22-1220
https://doi.org/10.1115/1.4056173
Published Online: December 9, 2022
View Articletitled, Biot Theory-Based Finite Element Modeling of Continuous Ultrasound Propagation Through Microscale Articular Cartilage
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Topics: Cartilage, Chondrocytes, Finite element methods, Fluids, Microscale devices, Ultrasound, Young's modulus, Materials properties, Displacement, Energy dissipation
Includes: Supplementary data
Journal Articles

Dynamic Deformation Calculation of Articular Cartilage and Cells Using Resonance-Driven Laser Scanning Microscopy

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Scott C. Sibole, Eng Kuan Moo, Salvatore Federico, Walter Herzog
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2023, 145(2): 021005.
Paper No: BIO-22-1117
https://doi.org/10.1115/1.4055308
Published Online: October 6, 2022
View Articletitled, Dynamic Deformation Calculation of Articular Cartilage and Cells Using Resonance-Driven Laser Scanning Microscopy
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Topics: Biological tissues, Cartilage, Chondrocytes, Deformation, Image registration, Image segmentation, Resonance, Osmosis, Computer software, Imaging
Journal Articles

Development of a Porcine Model to Assess the Effect of In Situ Knee Joint Loading on Site-Specific Cartilage Gene Expression

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Baaba S. Otoo, LePing Li, David A. Hart, Walter Herzog
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2022, 144(2): 024502.
Paper No: BIO-20-1018
https://doi.org/10.1115/1.4051922
Published Online: September 30, 2021
View Articletitled, Development of a Porcine Model to Assess the Effect of In Situ Knee Joint Loading on Site-Specific Cartilage Gene Expression
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Topics: Biological tissues, Cartilage, Knee, Stress, Chondrocytes, RNA
Includes: Supplementary data
Journal Articles

A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs

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Sophia Leung, Jung-Joo Kim, David S. Musson, Sue R. McGlashan, Jillian Cornish, Iain Anderson, Vickie B. K. Shim
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2021, 143(8): 084503.
Paper No: BIO-20-1362
https://doi.org/10.1115/1.4051116
Published Online: June 16, 2021
View Articletitled, A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs
Open the PDF for A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs in another window
Topics: Chondrocytes, Compression, Design, Hydrogels, Shear (Mechanics), Stress, Deformation, Agar, Tension
Includes: Supplementary data
Journal Articles

Local Strain Distribution and Increased Intracellular Ca 2+ Signaling in Bovine Articular Cartilage Exposed to Compressive Strain

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Wenjing Huang, Minami Nagasaka, Katsuko S. Furukawa, Takashi Ushida
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2020, 142(6): 061008.
Paper No: BIO-19-1061
https://doi.org/10.1115/1.4045807
Published Online: March 27, 2020
View Articletitled, Local Strain Distribution and Increased Intracellular Ca 2+ Signaling in Bovine Articular Cartilage Exposed to Compressive Strain
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Topics: Cartilage, Chondrocytes, Compression, Signals
Includes: Supplementary data
Journal Articles

Cartilage Biomechanical Response Differs Under Physiological Biaxial Loads and Uniaxial Cyclic Compression

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Ali Shegaf, Andrew Speirs
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. May 2020, 142(5): 054501.
Paper No: BIO-19-1313
https://doi.org/10.1115/1.4045661
Published Online: February 19, 2020
View Articletitled, Cartilage Biomechanical Response Differs Under Physiological Biaxial Loads and Uniaxial Cyclic Compression
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Topics: Biological tissues, Biomechanics, Cartilage, Compression, Fluid pressure, Fluids, Physiology, Stress, Simulation, Chondrocytes
Journal Articles

Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli

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Roy J. Lycke, Michael K. Walls, Sarah Calve
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2019, 141(8): 081002.
Paper No: BIO-18-1256
https://doi.org/10.1115/1.4043208
Published Online: May 6, 2019
View Articletitled, Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli
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Topics: Biological tissues, Cartilage, Chondrocytes, Finite element analysis, Geometry, Simulation, Stiffness, Engineering simulation, Materials properties, Computer simulation
Includes: Supplementary data
Journal Articles

The Effects of Dynamic Loading on Bone Fracture Healing Under Ilizarov Circular Fixators

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Ganesharajah Ganadhiepan, Lihai Zhang, Saeed Miramini, Priyan Mendis, Minoo Patel, Peter Ebeling, Yulong Wang
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2019, 141(5): 051005.
Paper No: BIO-18-1295
https://doi.org/10.1115/1.4043037
Published Online: March 25, 2019
View Articletitled, The Effects of Dynamic Loading on Bone Fracture Healing Under Ilizarov Circular Fixators
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Topics: Bone, Bone fractures, Chondrocytes, Diffusion (Physics), Dynamic testing (Materials), Fibroblasts, Fracture (Materials), Fracture (Process), Osteoblasts, Pellet fusion
Journal Articles

Finite Element Formulation of Multiphasic Shell Elements for Cell Mechanics Analyses in FEBio

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Jay C. Hou, Steve A. Maas, Jeffrey A. Weiss, Gerard A. Ateshian
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2018, 140(12): 121009.
Paper No: BIO-18-1171
https://doi.org/10.1115/1.4041043
Published Online: September 25, 2018
View Articletitled, Finite Element Formulation of Multiphasic Shell Elements for Cell Mechanics Analyses in FEBio
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Topics: Chondrocytes, Membranes, Shells, Finite element analysis, Deformation
Journal Articles

Moderate Cyclic Tensile Strain Alters the Assembly of Cartilage Extracellular Matrix Proteins In Vitro

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Judith Bleuel, Frank Zaucke, Gert-Peter Brüggemann, Juliane Heilig, Marie-Louise Wolter, Nina Hamann, Sara Firner, Anja Niehoff
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2015, 137(6): 061009.
Paper No: BIO-14-1497
https://doi.org/10.1115/1.4030053
Published Online: June 1, 2015
View Articletitled, Moderate Cyclic Tensile Strain Alters the Assembly of Cartilage Extracellular Matrix Proteins In Vitro
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Topics: Cartilage, Chondrocytes, Proteins, Manufacturing
Includes: Supplementary data
Journal Articles

Effects of Cryopreservation on the Depth-Dependent Elastic Modulus in Articular Cartilage and Implications for Osteochondral Grafting

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David Kahn, Clifford Les, Yang Xia
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. May 2015, 137(5): 054502.
Paper No: BIO-14-1413
https://doi.org/10.1115/1.4029182
Published Online: May 1, 2015
View Articletitled, Effects of Cryopreservation on the Depth-Dependent Elastic Modulus in Articular Cartilage and Implications for Osteochondral Grafting
Open the PDF for Effects of Cryopreservation on the Depth-Dependent Elastic Modulus in Articular Cartilage and Implications for Osteochondral Grafting in another window
Topics: Biological tissues, Biomechanics, Cartilage, Chondrocytes, Cryonics, Displacement, Elastic moduli, Stress
Journal Articles

Harnessing Biomechanics to Develop Cartilage Regeneration Strategies

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Kyriacos A. Athanasiou, Donald J. Responte, Wendy E. Brown, Jerry C. Hu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Forum
J Biomech Eng. February 2015, 137(2): 020901.
Paper No: BIO-14-1381
https://doi.org/10.1115/1.4028825
Published Online: February 1, 2015
View Articletitled, Harnessing Biomechanics to Develop Cartilage Regeneration Strategies
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Topics: Biological tissues, Biomechanics, Cartilage, Tissue engineering, Tensile strength, Chondrocytes, Self-assembly, Mechanical properties
Journal Articles

Determination of Strain-Rate-Dependent Mechanical Behavior of Living and Fixed Osteocytes and Chondrocytes Using Atomic Force Microscopy and Inverse Finite Element Analysis

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Trung Dung Nguyen, YuanTong Gu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2014, 136(10): 101004.
Paper No: BIO-13-1485
https://doi.org/10.1115/1.4028098
Published Online: August 6, 2014
View Articletitled, Determination of Strain-Rate-Dependent Mechanical Behavior of Living and Fixed Osteocytes and Chondrocytes Using Atomic Force Microscopy and Inverse Finite Element Analysis
Open the PDF for Determination of Strain-Rate-Dependent Mechanical Behavior of Living and Fixed Osteocytes and Chondrocytes Using Atomic Force Microscopy and Inverse Finite Element Analysis in another window
Topics: Atomic force microscopy, Chondrocytes, Finite element analysis, Mechanical behavior
Journal Articles

The Regional Sensitivity of Chondrocyte Gene Expression to Coactive Mechanical Load and Exogenous TNF-α Stimuli

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S. L. Bevill, K. A. Boyer, T. P. Andriacchi
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2014, 136(9): 091005.
Paper No: BIO-13-1579
https://doi.org/10.1115/1.4027937
Published Online: July 15, 2014
View Articletitled, The Regional Sensitivity of Chondrocyte Gene Expression to Coactive Mechanical Load and Exogenous TNF-α Stimuli
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Topics: Cartilage, Chondrocytes, Compression, Stress
Journal Articles

Computational Investigation of Fibrin Mechanical and Damage Properties at the Interface Between Native Cartilage and Implant

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Ali Vahdati, Yang Zhao, Timothy C. Ovaert, Diane R. Wagner
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2012, 134(11): 111004.
https://doi.org/10.1115/1.4007748
Published Online: October 26, 2012
View Articletitled, Computational Investigation of Fibrin Mechanical and Damage Properties at the Interface Between Native Cartilage and Implant
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Topics: Adhesives, Cartilage, Damage, Knee, Glues, Failure, Finite element model, Stress, Chondrocytes, Maintenance
Journal Articles

A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation

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Taly P. Appelman, Joseph Mizrahi, Dror Seliktar
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2011, 133(4): 041010.
https://doi.org/10.1115/1.4003314
Published Online: March 23, 2011
View Articletitled, A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation
Open the PDF for A Finite Element Model of Cell-Matrix Interactions to Study the Differential Effect of Scaffold Composition on Chondrogenic Response to Mechanical Stimulation in another window
Topics: Cartilage, Chondrocytes, Deformation, Engineering simulation, Finite element model, Hydrogels, Simulation, Stress, Finite element analysis, Biological tissues
Journal Articles

Evaluation of Negative Fixed-Charge Density in Tissue-Engineered Cartilage by Quantitative MRI and Relationship With Biomechanical Properties

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Shogo Miyata, Kazuhiro Homma, Tomokazu Numano, Tetsuya Tateishi, Takashi Ushida
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. July 2010, 132(7): 071014.
https://doi.org/10.1115/1.4001369
Published Online: June 2, 2010
View Articletitled, Evaluation of Negative Fixed-Charge Density in Tissue-Engineered Cartilage by Quantitative MRI and Relationship With Biomechanical Properties
Open the PDF for Evaluation of Negative Fixed-Charge Density in Tissue-Engineered Cartilage by Quantitative MRI and Relationship With Biomechanical Properties in another window
Topics: Biological tissues, Biomechanics, Cartilage, Chondrocytes, Density, Magnetic resonance imaging, Relaxation (Physics), Equilibrium (Physics), Agar
Journal Articles

Parametric Finite Element Analysis of Physical Stimuli Resulting From Mechanical Stimulation of Tissue Engineered Cartilage

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Omotunde M. Babalola, B.S., Lawrence J. Bonassar, Ph.D.
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. June 2009, 131(6): 061014.
https://doi.org/10.1115/1.3128672
Published Online: May 11, 2009
View Articletitled, Parametric Finite Element Analysis of Physical Stimuli Resulting From Mechanical Stimulation of Tissue Engineered Cartilage
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Topics: Biological tissues, Cartilage, Finite element analysis, Fluids, Permeability, Tissue engineering, Finite element model, Materials properties, Compression, Pressure
Journal Articles

Mechanical Characterization of Differentiated Human Embryonic Stem Cells

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Gidon Ofek, Vincent P. Willard, Eugene J. Koay, Jerry C. Hu, Patrick Lin, Kyriacos A. Athanasiou
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. June 2009, 131(6): 061011.
https://doi.org/10.1115/1.3127262
Published Online: May 8, 2009
View Articletitled, Mechanical Characterization of Differentiated Human Embryonic Stem Cells
Open the PDF for Mechanical Characterization of Differentiated Human Embryonic Stem Cells in another window
Topics: Biomechanics, Cartilage, Cellular mechanics, Chondrocytes, Creep, Density, Mechanical properties, Separation (Technology), Stem cells, Tissue engineering