Stroke caused by an embolism accounts for about a third of all stroke cases. Understanding the source and cause of the embolism is critical for diagnosis and long-term treatment of such stroke cases. The complex nature of the transport of an embolus within large arteries is a primary hindrance to a clear understanding of embolic stroke etiology. Recent advances in medical image-based computational hemodynamics modeling have rendered increasing utility to such techniques as a probe into the complex flow and transport phenomena in large arteries. In this work, we present a novel, patient-specific, computational framework for understanding embolic stroke etiology, by combining image-based hemodynamics with discrete particle dynamics and a sampling-based analysis. The framework allows us to explore the important question of how embolism source manifests itself in embolus distribution across the various major cerebral arteries. Our investigations illustrate prominent numerical evidence regarding (i) the size/inertia-dependent trends in embolus distribution to the brain; (ii) the relative distribution of cardiogenic versus aortogenic emboli among the anterior, middle, and posterior cerebral arteries; (iii) the left versus right brain preference in cardio-emboli and aortic-emboli transport; and (iv) the source–destination relationship for embolisms affecting the brain.
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August 2016
Research-Article
Computational Assessment of the Relation Between Embolism Source and Embolus Distribution to the Circle of Willis for Improved Understanding of Stroke Etiology
Debanjan Mukherjee,
Debanjan Mukherjee
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
e-mail: debanjan@berkeley.edu
University of California, Berkeley,
Berkeley, CA 94720
e-mail: debanjan@berkeley.edu
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Neel D. Jani,
Neel D. Jani
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
Search for other works by this author on:
Kartiga Selvaganesan,
Kartiga Selvaganesan
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
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Christopher L. Weng,
Christopher L. Weng
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
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Shawn C. Shadden
Shawn C. Shadden
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
University of California, Berkeley,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
Search for other works by this author on:
Debanjan Mukherjee
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
e-mail: debanjan@berkeley.edu
University of California, Berkeley,
Berkeley, CA 94720
e-mail: debanjan@berkeley.edu
Neel D. Jani
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
Kartiga Selvaganesan
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
Christopher L. Weng
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
University of California, Berkeley,
Berkeley, CA 94720
Shawn C. Shadden
Department of Mechanical Engineering,
University of California, Berkeley,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
University of California, Berkeley,
Berkeley, CA 94720
e-mail: shadden@berkeley.edu
Manuscript received February 26, 2016; final manuscript received June 19, 2016; published online July 12, 2016. Assoc. Editor: Ender A. Finol.
J Biomech Eng. Aug 2016, 138(8): 081008 (13 pages)
Published Online: July 12, 2016
Article history
Received:
February 26, 2016
Revised:
June 19, 2016
Citation
Mukherjee, D., Jani, N. D., Selvaganesan, K., Weng, C. L., and Shadden, S. C. (July 12, 2016). "Computational Assessment of the Relation Between Embolism Source and Embolus Distribution to the Circle of Willis for Improved Understanding of Stroke Etiology." ASME. J Biomech Eng. August 2016; 138(8): 081008. https://doi.org/10.1115/1.4033986
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