Proper folding of the cerebral cortex is critical to normal human brain function. The mechanisms of cortical folding, however, remain incompletely understood, although they have intrigued neuroscientists for more than a century. Clearly a biomechanical problem, cortical folding has been speculated to result from stresses induced by differential or constrained growth . More recently, investigators have postulated that tension in neural axons of cerebral white matter causes specific folding patterns . However, it is uncertain if sustained tension exists in axons in both the developing and mature brain.
- Bioengineering Division
Residual Stress in the Mouse Brain
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Xu, G, Bayly, PV, & Taber, LA. "Residual Stress in the Mouse Brain." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 953-954. ASME. https://doi.org/10.1115/SBC2008-192205
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