A mathematical model of bubble growth in superheated liquid during rapid decompression was built up on the basis of non-equilibrium thermodynamics. According to the principles of thermodynamics it is asserted that the bubble growth process can be described by a polytropic process rather than assuming that it goes along the saturation curve as usually suggested in existing article. The value of the polytropic exponent n is restrict to a ranges of 1 ≤ n ≤ nσ < k to guarantee the existence of a positive driving force to drive the phase transition process. Numerical simulation of the bubble growth process was performed for water by using the model proposed. The results obtained were compared with experimental data provided by other authors. Good agreement was achieved.