This paper presents a modeling framework for an intracellular signaling network based on formalisms derived from the fundamental concepts in probability theory. Cellular behavior is mediated by a network of intracellular protein activations that originate at the membrane in response to stimulation of cell surface receptors. Multiple protein signal transductions occur concurrently through diverse pathways triggered by different extracellular cues. Through crosstalk, these pathways intersect at various node proteins. The state of a particular node protein is dependent on the binding order of molecules from various pathways. The probability of a particular binding order is evaluated using state dependent transduction time probabilities associated with each pathway. In this way, the probability of the cell to be in a given internal state is tracked and used to gain insight into the cell’s phenotypic behavior. A simulation example illustrates the approach. Future work will incorporate the proposed method into the development of a feedback control strategy for the development of an in silico control design of endothelial cell migration during angiogenesis.
- Dynamic Systems and Control Division
A Time-Based Approach to Stochastic Modeling of Intracellular Signaling Events
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Mayalu, MN, & Asada, HH. "A Time-Based Approach to Stochastic Modeling of Intracellular Signaling Events." Proceedings of the ASME 2012 5th Annual Dynamic Systems and Control Conference joint with the JSME 2012 11th Motion and Vibration Conference. Volume 1: Adaptive Control; Advanced Vehicle Propulsion Systems; Aerospace Systems; Autonomous Systems; Battery Modeling; Biochemical Systems; Control Over Networks; Control Systems Design; Cooperative and Decentralized Control; Dynamic System Modeling; Dynamical Modeling and Diagnostics in Biomedical Systems; Dynamics and Control in Medicine and Biology; Estimation and Fault Detection; Estimation and Fault Detection for Vehicle Applications; Fluid Power Systems; Human Assistive Systems and Wearable Robots; Human-in-the-Loop Systems; Intelligent Transportation Systems; Learning Control. Fort Lauderdale, Florida, USA. October 17–19, 2012. pp. 579-583. ASME. https://doi.org/10.1115/DSCC2012-MOVIC2012-8631
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